璩肩墿淇濋殰
鏀粯鏂瑰紡
閰嶉€佹湇鍕�(w霉)
鍞悗鏈嶅嫏(w霉)
闂�(gu膩n)浜庢垜鍊�
鍒╂櫘鍗擄紙濂ф媺甯曞埄鐗囷級妯傚ぇ钘ユ埧璩艰棩鍍规牸鍎�(y艒u)鎯�锛岀泭钘ュ悍寰锋▊澶ц棩鎴挎槸鍦嬪姝ｈ(gu墨)瀹樼恫(w菐ng)钘ュ簵锛屽湪鍏ㄥ湅澶氬湴鍗€(q奴)鍧囨湁鍒嗗簵锛屽悇鍒嗗簵鍦板潃鍙櫥闄哥泭钘ュ悍寰锋▊澶ц棩鎴垮畼鏂圭恫(w菐ng)绔欐煡鐪�?锛涢鍜磋皯涓璯(sh霉)鍚庨渶瑕佽嚗搴婁紤鎭�锛岄€欐檪鍊欒娉ㄦ剰鎮ｈ€呯殑鑷ュЭ锛岃畵鎮ｈ€呯殑闋儴鍋忓悜涓€閭�锛岄伩鍏嶅嚭鐝�(xi脿n)绐掓伅绛夊毚(y谩n)閲嶅悗鏋溿€� 瑭虫儏
濂ф媺甯曞埄鐗囧嚭鍞児鏍煎苟娌掓湁寰堟槀璨�锛屼笉閬庣暥(d膩ng)鍓嶅湪甯傞潰涓婂悇澶у楂旇棩搴楃殑璩ｅ児涔熶笉鏄悓涓€妯�(bi膩o)婧�(zh菙n)鐨�锛屽悇浣嶅鏋滄兂瑕佷簡瑙ｅ叿楂旀儏娉�锛屽彲浠ユ娊鏅傞枔鍘荤泭钘ュ悍寰锋▊澶ц棩鎴垮挩瑭竴涓嬪皥妤�(y猫)浜哄＋銆� 瑭虫儏
濂ф媺甯曞埄鐗囨帹钖﹀姂閲忕偤300mg锛�2鐗�150mg鐗囧姂锛�锛屾瘡鏃�2娆�锛岀浉鐣�(d膩ng)浜庢瘡鏃ョ附鍔戦噺鐐�600mg锛�100mg鐗囧姂鐢ㄤ簬鍔戦噺娓涘皯鏅備娇鐢�锛屽灞噳(y墨ng)瑭茬洠(ji膩n)鐫ｆ偅鑰呮寜鐓ф纰虹殑鏂规硶锛屾纰虹殑鐢ㄩ噺鍘讳娇鐢ㄨ紨鍔╂不鐧傜柧鐥呯殑钘ュ搧锛岀洝閲忎笉瑕佺櫦(f膩)鐢熼亷閲忕敤钘ョ殑鎯呮硜锛屽苟涓旂敤钘ラ殠娈典篃鎳�(y墨ng)瑭茬潱淇冧粬鍊戣獚(r猫n)鐪熷仛濂芥敞鎰忎簨闋�銆� 瑭虫儏
濂ф媺甯曞埄鐗囩蹇岋細灏嶈棩鐗╂椿鎬ф垚鍒嗘垨浠讳綍杓旀枡鎴愪唤閬庢晱鑰呯鐢紝娌荤檪鏈熼枔鍜屾湯娆＄郸钘ュ悗1鍊嬫湀鍏�(n猫i)鍋滄鍝轰钩锛堝弮瑕媅瀛曞│鍙婂摵涔虫湡濠﹀コ鐢ㄨ棩]锛�锛屾垜鍊戞噳(y墨ng)瑭插湪灏堟キ(y猫)浜哄＋鎸囧皫(d菐o)涓嬮伕鎿囧悎閬╄嚜宸辩殑钘ョ墿锛屽皪鐤剧梾閫茶娌荤檪锛岃€屼笖鎺ュ彈娌荤檪閬庣▼涓篃鏄渶瑕佸畾鏈熷京(f霉)鏌ョ殑銆� 瑭虫儏
鍒╂櫘鍗擄紙濂ф媺甯曞埄鐗囷級閬╂噳(y墨ng)鐧ワ細鏀滃付鑳氱郴鎴栭珨绱�(x矛)鑳濨RCA绐佽畩鐨勶紙gBRCAm鎴杝BRCAm锛夋櫄鏈熶笂鐨€у嵉宸㈢檶銆佽几鍗电鐧屾垨鍘熺櫦(f膩)鎬ц吂鑶滅檶鍒濇不鎴愪汉鎮ｈ€呭湪涓€绶氬惈閴戝寲鐧傞仈鍒板畬鍏ㄧ珐瑙ｆ垨閮ㄥ垎绶╄В鍚庣殑缍寔娌荤檪?锛涢鍜€垛拋閳р偓浜洪２椋熺殑瑾�(di脿o)鐞嗭紝瑕侀伕鎿囨湁鐕熼(y菐ng)鏄撴秷鍖栫殑椋熺墿銆� 瑭虫儏
鍒╂櫘鍗擄紙濂ф媺甯曞埄鐗囷級涓嶈壇鍙嶆噳(y墨ng)锛氱敱浜庤嚚搴婅│鏁村绋笉鍚岀殑姊濅欢涓嬪睍闁�锛屽洜姝や竴绋棩鐗╁湪鑷ㄥ簥瑭﹂涓瀵熷埌鐨勪笉鑹弽鎳�(y墨ng)鐧�(f膩)鐢熺巼涓嶈兘鑸囧拰钘ョ墿鍦ㄤ織搴婅│椹椾腑瑙€瀵熷埌鐨勪笉鑹弽鎳�(y墨ng)鐧�(f膩)鐢熺巼閫茶鐩存帴姣旇純锛屽苟涓斾篃涓嶈兘鍙嶆槧鑷ㄥ簥瀵﹁笎瑙€瀵熷埌鐨勭櫦(f膩)鐢熺巼銆傛偅鑰呰瀹氭湡鍘婚啱(y墨)闄㈠氨瑷烘鏌ヤ簡瑙ｈ嚜宸辩殑鐥呮儏璁婂寲銆� 瑭虫儏
濂ф媺甯曞埄鐗囨槸鍚﹁璺熷叾浠栬棩鐗╄伅(li谩n)鍚堜娇鐢紝鏄笉鑳借嚜宸辨焙瀹氱殑锛屾垜鍊戞噳(y墨ng)瑭插悜?q奴)顥滻(y猫)浜哄＋鍜ㄨ涓€涓嬶紝瑕佺祼(ji茅)鍚堣嚜宸辩殑韬珨鎯呮硜鍘诲仛姹哄畾锛岃€屼笖鍦ㄦ惌閰嶇敤钘ラ亷绋嬩腑锛屼篃鎳�(y墨ng)瑭蹭粩绱�(x矛)瑙€瀵熶竴涓嬭韩楂旂媭娉侊紝濡傛灉鏈夊壇浣滅敤鐧�(f膩)鐢�锛岃鍙婃檪閲囧彇鎺柦铏曠悊銆� 瑭虫儏
鍒╂櫘鍗擄紙濂ф媺甯曞埄鐗囷級娉ㄦ剰浜嬮爡锛氳娑插(xu茅)姣掓€у湪鎺ュ彈鏈搧娌荤檪鐨勬偅鑰呬腑鍫卞憡浜嗚娑插(xu茅)姣掓€�,鍖呮嫭杓曞害鎴栦腑搴︼紙CTCAE1绱氭垨2绱氾級璨ц銆佷腑鎬х矑绱�(x矛)鑳炴笡灏戠櫏銆佽灏忔澘娓涘皯鐧ュ拰娣嬪反绱�(x矛)鑳炴笡灏戠櫏鐨勮嚚搴婅ê鏂峰拰/鎴�?q奴)宥掔倗瑕歾鏌ョ祼(ji茅)鏋�銆� 瑭虫儏
鍒╂櫘鍗擄紙濂ф媺甯曞埄鐗囷級鐩婅棩搴峰痉妯傚ぇ钘ユ埧鏄彲浠ヨ卜鍒拌棩鐗╃殑锛屽缓璀伴渶瑕佺殑浜鸿鍒颁竴浜涙瑕�(gu墨)鐨勫ぇ钘ユ埧閫茶璩艰卜锛屾瑕�(gu墨)鍦版柟璨峰埌鐨勮棩鐗╂偅鑰呰兘鏀惧績閫茶浣跨敤銆� 瑭虫儏
鍒╂櫘鍗擄紙濂ф媺甯曞埄鐗囷級鐢ㄦ硶鐢ㄩ噺锛氭帹钖﹀姂閲忔湰鍝佹湁150mg鍜�100mg瑕�(gu墨)鏍�銆傛帹钖﹀姂閲忕偤300mg锛�2鐗�150mg鐗囧姂锛夛紝姣忔棩2娆�锛岀浉鐣�(d膩ng)浜庢瘡鏃ョ附鍔戦噺鐐�600mg銆傚ェ鎷夊笗鍒╃墖浣滅敤鐥呬汉瑕佸浜嗚В锛岀暥(d膩ng)鐒朵篃瑕佹帉鎻¤棩鐗╃殑娉ㄦ剰浜嬮爡鎴栬€呰棩鐗╃殑鍏朵粬鍏�(n猫i)瀹�锛屽鐪嬩竴涓嬮€欎簺鍩烘湰淇℃伅銆� 瑭虫儏
渚嗘洸鍞戠墖瑾槑鏇歌棩鐞嗕綔鐢細渚嗘洸鍞戞槸鑺抽鍖栭叾绯荤当(t菕ng)鐨勪竴绋潪椤炲浐閱囩鐖€ф姂鍒跺姂锛岀禃缍�(j墨ng)鍚庡│濂抽珨鍏�(n猫i)鐨勯泴婵€绱犱富瑕佷緷璩翠簬鑺抽鍖栭叾灏囪厧涓婅吅鐨唱(zh矛)鍒嗘硨鐨勯泟婵€绱犺綁(zhu菐n)鍖栫偤闆屾縺绱狅紝渚嗘洸鍞戠偤鑺抽鍖栭叾鎶戝埗鍔�锛岄€氶亷鎶戝埗鑺抽鍖栭叾鐨勫悎鎴�锛屽緸鑰屾笡灏戜簡闆勬縺绱犲悜闆屾縺绱犵殑杞�(zhu菐n)鍖�锛岄檷浣庝簡楂斿収(n猫i)闆屾縺绱犵殑姘村钩銆傞€欎竴钘ョ墿闇€瑕佸瘑灏侀€茶淇濆瓨銆� 瑭虫儏
濂ф媺甯曞埄鐗囧彲浠ュ埌瀵﹂珨钘ュ簵璩艰卜鐨勶紝涓嶉亷璨疯棩鐨勬檪鍊欐噳(y墨ng)瑭茶(j菒n)鎱庝竴榛�锛屽皪钘ョ墿璩�(zh矛)閲忚鍤�(y谩n)鏍兼妸闂�(gu膩n)锛屼竴瀹氳瑾�(r猫n)婧�(zh菙n)鐢熺敘(ch菐n)寤犲璩艰卜锛屽悓鏅備篃瑕佷粩绱�(x矛)鐪嬩竴涓嬬敓鐢�(ch菐n)鏃ユ湡锛屾敞鎰忎笉瑕佷娇鐢ㄩ亷鏈熻棩鐗╂垨鍋藉姡钘ョ墿鍘昏紨鍔╂不鐧傜柧鐥�銆� 瑭虫儏
濂ф媺甯曞埄鐗囩敤娉曠敤閲忥細鎺ㄨ枽鍔戦噺鏈棩鍝佹湁150mg鍜�100mg瑕�(gu墨)鏍�锛屾帹钖﹀姂閲忕偤300mg锛�2鐗�150mg鐗囧姂锛�锛屾瘡鏃�2娆�锛岀浉鐣�(d膩ng)浜庢瘡鏃ョ附鍔戦噺鐐�600mg锛�100mg鐗囧姂鐢ㄤ簬鍔戦噺娓涘皯鏅備娇鐢�锛屾偅鑰呮噳(y墨ng)鍦ㄥ惈閴戝寲鐧傜祼(ji茅)鏉熷悗鐨�8鍛ㄥ収(n猫i)闁嬪鏈棩鍝佹不鐧�锛屽湪鎮ｈ€呬娇鐢ㄨ棩鐗╅殠娈碉紝瀹跺爆鎳�(y墨ng)瑭插湪涓€鏃佸仛濂界洠(ji膩n)鐫ｅ伐浣�锛岃鐫ｄ績鎮ｈ€呮寜鏅傛寜閲忕敤钘ワ紝涓嶈鑷瑾�(di脿o)鏁寸敤閲�锛屼篃瑕佺潱淇冧粬鍊戝仛濂界浉闂�(gu膩n)娉ㄦ剰浜嬮爡銆� 瑭虫儏
濂ф媺甯曞埄鐗囩敤娉曠敤閲忥細鎺ㄨ枽鍔戦噺鐐�300mg锛�2鐗�150mg鐗囧姂锛�锛屾瘡鏃�2娆�锛岀浉鐣�(d膩ng)浜庢瘡鏃ョ附鍔戦噺鐐�600mg锛�100mg鐗囧姂鐢ㄤ簬鍔戦噺娓涘皯鏅備娇鐢�锛屾偅鑰呮噳(y墨ng)鍦ㄥ惈閴戝寲鐧傜祼(ji茅)鏉熷悗鐨�8鍛ㄥ収(n猫i)闁嬪鏈棩鍝佹不鐧�锛屽灞噳(y墨ng)瑭茬洠(ji膩n)鐫ｆ偅鑰呮纰虹敤钘ュ皪鐤剧梾閫茶娌荤檪锛屽苟涓斾篃鎳�(y墨ng)瑭茬潱淇冧粬鍊戣獚(r猫n)鐪熷仛濂界敤钘ラ殠娈电殑娉ㄦ剰浜嬮爡锛屼互鍏嶅奖闊垮埌钘ユ晥鐧�(f膩)鎻�銆� 瑭虫儏
濂ф媺甯曞埄鐗囩蹇岋細灏嶈棩鐗╂椿鎬ф垚鍒嗘垨浠讳綍杓旀枡鎴愪唤閬庢晱鑰呯鐢�锛屾不鐧傛湡闁撳拰鏈绲﹁棩鍚�1鍊嬫湀鍏�(n猫i)鍋滄鍝轰钩锛堝弮瑕媅瀛曞│鍙婂摵涔虫湡濠﹀コ鐢ㄨ棩]锛�锛屾垜鍊戞噳(y墨ng)瑭茬祼(ji茅)鍚堣嚜宸辩殑韬珨鎯呮硜鍘婚伕鎿囨不鐧傜柧鐥呯殑钘ュ搧锛岀敤钘ユ噳(y墨ng)瑭茶(j菒n)鎱�锛屼笉瑕佸挤琛屼娇鐢ㄩ偅浜涗笉閬╁悎鑷繁鐨勮棩鍝�銆� 瑭虫儏
濂ф媺甯曞埄鐗囪€佸勾鐢ㄨ棩鏄湪鍏ラ伕687鍚嶆櫄鏈熷楂旂槫鎮ｈ€呮帴鍙楀ェ鎷夊笗鍒╃墖鍔�300mg姣忔棩2娆�锛屼綔鐐哄柈钘ユ不鐧傜殑鑷ㄥ簥鐮旂┒涓紝146鍚嶏紙21锛咃級鎮ｈ€呭勾榻♀墺65姝�锛屽寘鎷�29锛�4锛咃級鑰呭勾榻♀墺75姝�锛屾矑鏈夋偅鑰呭勾榻♀墺85姝�?锛熷仧鑶╃f锛岃€佸勾浜虹敤钘ヨ璎�(j菒n)鎱庡皪寰�锛屼竴瀹氳閬甸啱(y墨)鍥戦€茶銆� 瑭虫儏
绱呴噾娑堢祼(ji茅)鑶犲泭鐩婅棩搴峰痉妯傚ぇ钘ユ埧鏈夐姺鍞�锛岄€氶亷姝ｈ(gu墨)鍦版柟渚嗛€茶钘ョ墿鐨勮臣璨�锛岀梾浜哄彲浠ユ斁蹇冪殑閫茶浣跨敤銆傜暥(d膩ng)鐒跺皪浜庡瓙瀹倢鐦ら櫎浜嗚閫氶亷钘ョ墿閫茶瑾�(di脿o)鐞�锛屽钩鏅傝娉ㄦ剰瑕侀(y菐ng)鎴愬ソ鐨勯２椋熺繏(x铆)鎱�锛岃€屼笖閭勮娉ㄦ剰瑕佸畾鏈熷埌閱�(y墨)闄㈠仛韬珨鐨勬鏌�锛岄€欎簺灏嶇柧鐥呬篃鏄湁闋�(y霉)闃蹭綔鐢ㄧ殑銆� 瑭虫儏
濂ф媺甯曞埄鐗囦笉鑹弽鎳�(y墨ng)鏄敱浜庤嚚搴婅│鏁村绋笉鍚岀殑姊濅欢涓嬪睍闁嬶紝鍥犳涓€绋棩鐗╁湪鑷ㄥ簥瑭﹂涓瀵熷埌鐨勪笉鑹弽鎳�(y墨ng)鐧�(f膩)鐢熺巼涓嶈兘鑸囧拰钘ョ墿鍦ㄤ織搴婅│椹椾腑瑙€瀵熷埌鐨勪笉鑹弽鎳�(y墨ng)鐧�(f膩)鐢熺巼閫茶鐩存帴姣旇純锛屽苟涓斾篃涓嶈兘鍙嶆槧鑷ㄥ簥瀵﹁笎瑙€瀵熷埌鐨勭櫦(f膩)鐢熺巼?锛涢鍜儴顎緈鐣�(d膩ng)韬珨鐙€娉�锛岄伕鎿囬仼鍚堣嚜宸辩殑閬嬪嫊鏂瑰紡銆� 瑭虫儏
涓嶈壇鍙嶆噳(y墨ng)鏄棩鐗╀俊鎭箣涓€锛屾偅鑰呭钩鏅傚彲浠ュ鍘讳簡瑙ｅ拰闂�(gu膩n)娉�銆傚叾涓盁浠栬兒鐗囦笉鑹弽鎳�(y墨ng)锛氱敺鎬т钩鎴垮コ鎬у寲锛屼钩鎴胯Ц鐥�锛屾湁鏅備即鏈夋孩涔�锛屽娓涘皯鍔戦噺鎴栧仠钘ュ墖鍙秷澶�锛涘皯鏁�(sh霉)鎮ｈ€呭彲鏈夎吂鐎�銆佹儭蹇冦€佸様鍚愩€侀娆插鍔�銆佸け鐪犲拰鐤插嫗锛涚綍瑕嬫€ф娓涗綆銆佷竴閬庢€ц倽鍔熻兘鐣板父鍙婄簿瀛愯▓鏁�(sh霉)娓涘皯銆傛湰鍝佸皪蹇冭绠＄殑娼涘湪鎬у奖闊挎瘮宸辩儻闆岄厷灏�銆� 瑭虫儏
姘熶粬鑳虹墖浣滅偤娌荤檪鍓嶅垪鑵虹檶鐨勮檿鏂硅棩鐗�锛岄暦鏈熶娇鐢ㄦ檪闇€娉ㄦ剰瀹氭湡妾㈡煡鑲濊嚐鍔熻兘浠ュ強鐩�(ji膩n)娓簿瀛愭暩(sh霉)閲�锛屽苟鍋氬ソ鐩搁棞(gu膩n)璀风悊鎺柦銆傛湰鍝佷富瑕侀仼鐢ㄤ簬鍓嶅垪鑵虹檶锛屽皪鍒濇不鍙婂京(f霉)娌荤梾浜哄潎鏈変竴瀹氬姛鏁�銆傛偅鑰呭湪浣跨敤閬庣▼涓噳(y墨ng)鍤�(y谩n)鏍奸伒寰啱(y墨)鐢熺殑鎸囧皫(d菐o)锛屾寜鏅傞€茶鐩搁棞(gu膩n)妾㈡煡锛屼互渚垮強鏅傜櫦(f膩)鐝�(xi脿n)鍜岃檿鐞嗗彲鑳藉嚭鐝�(xi脿n)鐨勪笉鑹弽鎳�(y墨ng)銆� 瑭虫儏
姝ｅ搧淇濋殰 鏀惧績閬歌臣
鐢ㄨ棩鍏ㄧ▼鎸囧皫(d菐o)
寤犲鎺堟瑠(qu谩n) 姝ｅ搧娓犻亾
瀹夊叏鏀惧績 闅辩閰嶉€�
