璩肩墿淇濋殰
鏀粯鏂瑰紡
閰嶉€佹湇鍕�(w霉)
鍞悗鏈嶅嫏(w霉)
闂�(gu膩n)浜庢垜鍊�
寰�(f霉)鏂规枒铦ヨ啝鍥婄偤鎶楃檶钘ョ墿锛岃棩鐗╃牬琛€娑堢榾锛屾敾姣掕潟鐦�锛涚敤浜庡師鐧�(f膩)鎬ц倽鐧�銆佽偤鐧�銆佺洿鑵哥檶銆佹儭鎬ф穻宸寸槫銆佸│绉戞儭鎬ц叓鐦ょ瓑锛岃棩鐗╃殑绂佸繉锛氬瓡濠︾鐢ㄣ€傚厭绔ユ湁鐩搁棞(gu膩n)鐨勭梾鎯呭嚭鐝�(xi脿n)鏄彲浠ヨ€冩叜鐢ㄨ棩鐨�锛屼笉閬庡厭绔ョ敤钘ユ檪鍊欑殑鍔戦噺鍜屾檪闁撻渶瑕侀€�(j矛n)琛屽毚(y谩n)鏍肩殑鎺у埗銆� 瑭虫儏
鐣�(d膩ng)鍓�锛屽笇缇呴仈(d谩)鐨勮純鐐哄悎鐞�锛岃€岀殑鎬х媭锛�0.15g锛岄洐鍑�銆侀暦鏂瑰舰銆佹泛妗冭壊鍖呰。鐗�锛岄櫎鍘诲寘琛ｅ悗椤櫧鑹�锛涗竴闈㈡湁XELODA瀛楁ǎ锛屽彟涓€闈㈡湁150瀛楁ǎ锛�0.5g锛岄洐鍑�銆侀暦鏂瑰舰銆佹鑹插寘琛ｇ墖锛岄櫎鍘诲寘琛ｅ悗椤櫧鑹�锛涗竴闈㈡湁XELODA瀛楁ǎ锛屽彟涓€闈㈡湁500瀛楁ǎ銆� 瑭虫儏
鐩婃櫘鑸掗仼鐢ㄤ簬鏀剧檪鎴栧寲鐧傚紩璧风殑鍙ｈ厰娼扮槏鐨勮钃�锛岀暥(d膩ng)鏈夐€欐柟闈㈢殑鍟忛鍑虹従(xi脿n)鏅傚氨鍙互鑰冩叜鍘昏臣璨疯棩鐗╀締浣跨敤锛涜€屽湪璨峰埌涔嬪悗瑕佹纰虹殑淇濆瓨锛屾湰钘ョ墿闇€瑕佹斁缃湪鍏掔涓嶅彲瑙稿強鐨勫湴鏂癸紱鐡跺瓙甯跺鐩掑婧帛瀛�锛涗竴鐡舵噳(y墨ng)鍍呬緵涓€浜轰娇鐢�锛涜珛鍕垮湪鐡跺瓙涓婃(bi膩o)鏄庣殑澶辨晥鏃ユ湡鍚庝娇鐢�锛涚摱瀛愰枊鍟熷悗鎳�(y墨ng)鍦�3鍊嬫湀鍏�(n猫i)浣跨敤銆� 瑭虫儏
鐧岀櫏鏅傛湁鐧�(f膩)鐢燂紝寤鸿閰嶅悎閱�(y墨)鐢熸帴鍙楄棩鐗╂不鐧傛帶鍒惰嚜韬殑鐥呮儏銆傚钩娑堢墖鎴愪唤锛氶儊閲�銆佷粰槎磋崏銆佷簲闈堣剛銆佺櫧绀€佸共婕嗭紙鍒讹級銆侀憨鐐掓灣娈笺€侀Μ閷㈠瓙绮�锛涙牴鎿�(j霉)钘ョ墿鐨勮鏄庢浉锛岃棩鐗╁湪浣跨敤涔嬪悗灏戣鎯″績锛岃棩鐤癸紝鍋惰闋殘锛岃吂鐎夛紱鍋滆棩鍚庝笂杩扮櫏鐙€鍙嚜琛屾秷澶�銆� 瑭虫儏
璨濅紣鐝犲柈鎶楁敞灏勬恫淇濆瓨鏂规硶瑾槑鏇告槸鏈変粙绱圭殑锛�2鈩�-8鈩�锛岄伩鍏変繚瀛樺拰閬�(y霉n)杓搞€傞伩鍏嶅喎鍑�銆傞伩鍏嶅妵鐑堟尟钑�銆傚缓璀板ぇ瀹惰浜嗚В閫欎簺淇℃伅锛岀劧鍚庝締鍋氬ソ灏嶆噳(y墨ng)鐨勮檿鐞嗭紝閫欐钘ョ墿闁嬪皝鍚庝竴鑸笉瀹滆秴閬�24灏忔檪锛屾墍浠ュ湪浣跨敤钘ョ墿鐨勬檪鍊�锛岃澶氫簡瑙ｉ€欎簺鍏�(n猫i)瀹�銆� 瑭虫儏
璨濅紣鐝犲柈鎶楁敞灏勬恫鍦ㄤ娇鐢ㄨ棩鐗╂湡闁撴湁浜涗汉鍙兘鏈冨瓨鍦ㄥ壇浣滅敤鐨�锛屼竴鑸渻鍑虹従(xi脿n)鐤插嫗涔忓姏銆佽吂鐎�銆佽吂鐥�銆侀珮琛€澹撶瓑鐧ョ媭锛岀梾浜鸿閰嶅悎閱�(y墨)甯敤钘ワ紝鑰屼笖钘ョ墿闀锋檪闁撲娇鐢ㄦ槸闇€瑕佸皪韬珨鐨勪竴浜涘櫒瀹橀€�(j矛n)琛屾鏌ョ殑锛屼互鍏嶅奖闊垮仴搴�銆� 瑭虫儏
璨濅紣鐝犲柈鎶楁敞灏勬恫鐢ㄨ棩鏈熼枔鏈夎ū澶氭敞鎰忎簨闋呯梾浜洪兘瑕佷簡瑙ｆ竻妤�锛岃鏄庢浉鏈夐€欐柟闈俊鎭粙绱逛簡锛屾垨鑰呰鏍规摎(j霉)鐥呮儏渚嗙敤钘ワ紝鑰屼笖鏈変簺钘ョ墿鏄笉寤鸿闀锋檪闁撲娇鐢ㄧ殑锛屼笉鐒跺彲鑳芥渻褰遍熆鍒拌倽鑵�锛屾墍浠ヨ璎�(j菒n)鎱庣殑浣跨敤钘ョ墿銆傚钩鏅傚湪鏃ュ父鐢熸椿涓�锛屽ぇ瀹朵篃瑕佹敞鎰忛伩鍏嶅湪姹℃煋鍤�(y谩n)閲嶇殑鐠�(hu谩n)澧冪殑鐢熸椿锛屽ぇ瀹堕倓瑕佹敞鎰忓悆涓€浜涙竻娣＄殑椋熺墿渚嗛€�(j矛n)琛岃韩楂旂殑瑾�(di脿o)鐞嗐€� 瑭虫儏
璨濅紣鐝犲柈鎶楁敞灏勬恫鎺ㄨ枽鍔戦噺鐐�:鑱�(li谩n)鍚堝寲鐧傛柟妗堟檪锛�5mg/kg楂旈噸锛屾瘡鍏╁懆绲﹁棩涓€娆�锛屾垨7.5 mg/kg楂旈噸锛屾瘡3鍛ㄧ郸钘ヤ竴娆�銆傜敤钘ヤ笁鍊嬫湀闇€瑕佸仠钘ュ涔呬篃鏄拰鐥呬汉鐨勮韩楂旀儏娉佹湁闂�(gu膩n)绯荤殑锛屽缓璀板挩瑭㈤啱(y墨)甯�锛岀劧鍚庡仛濂借檿鐞嗭紝骞虫檪瑕佸仴搴风殑椋查锛屽彲浠ュ鍚冧竴浜涙灉钄鐨勯鐗╀締瑾�(di脿o)鐞嗚韩楂斻€� 瑭虫儏
璨濅紣鐝犲柈鎶楁敞灏勬恫銆傝鏄庢浉閲岄潰鏈夐棞(gu膩n)浜庣敤娉曠敤閲忎粙绱圭殑锛屼笉鍚岀殑鎮ｈ€呬娇鐢ㄦ柟娉曚笉涓€妯�锛岀梾浜鸿閰嶅悎閱�(y墨)甯締鐢ㄨ棩瑾�(di脿o)鐞�?锛涢鍝傜洘骞穥(di脿o)鐞嗚韩楂旀湡闁撲篃瑕佸浜嗚В閫欑ó鐤剧梾鐨勭梾鍥�锛岀劧鍚庡彲浠ユ牴鎿�(j霉)鐥呭洜渚嗗仛濂藉皪鎳�(y墨ng)鐨勮檿鐞嗐€� 瑭虫儏
閱�(y墨)闄㈠拰钘ユ埧鍑哄敭鐨勮棩鐗╁児鏍煎苟涓嶄竴妯ｏ紝澶у骞虫檪鍙互澶氬幓鍜ㄨ浜嗚В銆傚笇缇呴仈(d谩)閬╃敤浜� Dukes鈥楥 鏈�銆佸師鐧�(f膩)鑵槫鏍规不琛�(sh霉)鍚�銆侀仼浜庢帴鍙楁盁鍢у暥椤炶棩鐗╁柈鐛ㄦ不鐧傜殑绲�(ji茅)鑵哥檶鎮ｈ€呯殑鍠棩杓斿姪娌荤檪锛涘叾娌荤檪鐨勭劇鐥呯敓瀛樻湡 锛圖FS锛� 涓嶄簽浜� 5-姘熷翱鍢у暥鍜岀敳閰板洓姘憠閰歌伅(li谩n)鍚堟柟妗� 锛�5-FU/LV锛� 銆傞渶瑕佺敤钘�锛岃閬告搰姝ｈ(gu墨)鐨勮棩鎴挎垨鑰呮槸閱�(y墨)闄�銆� 瑭虫儏
甯岀緟閬�(d谩)鐨勬€х媭锛�0.15g锛岄洐鍑�銆侀暦鏂瑰舰銆佹泛妗冭壊鍖呰。鐗�锛岄櫎鍘诲寘琛ｅ悗椤櫧鑹�锛涗竴闈㈡湁XELODA瀛楁ǎ锛屽彟涓€闈㈡湁150瀛楁ǎ锛�0.5g锛岄洐鍑�銆侀暦鏂瑰舰銆佹鑹插寘琛ｇ墖锛岄櫎鍘诲寘琛ｅ悗椤櫧鑹诧紱涓€闈㈡湁XELODA瀛楁ǎ锛屽彟涓€闈㈡湁500瀛楁ǎ?锛涢鍛栨ⅱ鏍借矮寰篒鍒拌棩鐗╀箣鍚庯紝鎸夌収閱�(y墨)鐢熺殑鎸囧皫(d菐o)姝ｇ⒑鐨勭敤钘�銆� 瑭虫儏
铇囬仩(yu菐n)锛堟洸姘熷翱鑻锋浛鍖瑰槯鍟剁墖锛夋敞鎰忎簨闋咃細鐐轰簡鐩�(ji膩n)娓瘨鎬у弽鎳�(y墨ng)蹇呴爤鍦ㄩ枊濮嬫湰钘ュ搧娌荤檪涔嬪墠浠ュ強鏍规摎(j霉)闇€瑕佹娓叏琛€绱�(x矛)鑳炶▓鏁�(sh霉)锛岃嚦灏戝湪姣忎竴鍊嬬檪绋嬮枊濮嬩箣鍓嶆娓�?锛涢鍜磋皯瑜備滑姘ㄤ花姘夊睉?x矛)闁辫畝瑾槑鏇�锛屼簡瑙ｈ棩鐗╃殑鐢ㄦ硶銆佺敤閲忎互鍙婃敞鎰忎簨闋呯瓑锛屼互纰轰繚娌荤檪鐨勮(gu墨)鑼冩€�銆� 瑭虫儏
铇囬仩(yu菐n)锛堟洸姘熷翱鑻锋浛鍖瑰槯鍟剁墖锛夎帛钘忥細瀵嗗皝锛�30鈩冧互涓嬩繚瀛�銆傝棩鍝佽鏄庢浉鏄偅鑰呬簡瑙ｈ棩鍝佹€ц唱(zh矛)銆佺敤娉曠敤閲�銆佽帛钘忔浠�銆佹湁鏁堟湡绛夐噸瑕佷俊鎭殑渚嗘簮锛屽湪浣跨敤铇囬仩(yu菐n)涔嬪墠锛屾偅鑰呮噳(y墨ng)瑭崇窗(x矛)闁辫畝瑾槑鏇�锛屽苟閬靛惊鍏朵腑鐨勬寚灏�(d菐o)閫�(j矛n)琛岀敤钘ュ拰璨棌銆傞€欐ǎ涓嶅儏鍙互纰轰繚鐢ㄨ棩鐨勮(gu墨)鑼冩€�锛岄倓鍙互閬垮厤涓嶅繀瑕佺殑棰�(f膿ng)闅拰瑾よВ?銆� 瑭虫儏
铇囬仩(yu菐n)锛堟洸姘熷翱鑻锋浛鍖瑰槯鍟剁墖锛夌偤寰�(f霉)鏂瑰埗鍔�锛屼富瑕佹垚浠界偤鏇叉盁灏胯嫹鍜岄菇閰告浛鍖瑰槯鍟舵洸姘熷翱鑻�銆傚湪椋查涓婃偅鑰呮噳(y墨ng)閬垮厤椋熺敤杈涜荆銆佹补鑶�銆佸爡纭瓑鍒烘縺鎬ч鐗╋紝浠ユ笡灏戝皪鑵搁亾鐨勫埡婵€銆傚皪浜庡瓨鍦ㄧ嚐椁�(y菐ng)涓嶈壇鐨勬偅鑰�锛屽彲鍦ㄩ啱(y墨)鐢熷缓璀颁笅閫氶亷鑵稿収(n猫i)鐕熼(y菐ng)娑茬瓑鏂瑰紡閫�(j矛n)琛岀嚐椁�(y菐ng)瑁�(b菙)鍏呫€� 瑭虫儏
瀹夌董姹€瑾槑鏇哥殑娉ㄦ剰浜嬮爡鏄┏绱�(x矛)浠嬬垂鐨�锛屾墍浠ユ湁杞�(zhu菐n)绉绘€х祼(ji茅)鐩磋吀鐧岀殑鎮ｈ€呰鐪嬫竻妤氶€欏€嬭韩楂斿収(n猫i)瀹�锛屽彲浠ユ牴鎿�(j霉)鑷韩鐨勬儏娉佷締鍚堢悊鐨勭敤钘ヨ(di脿o)鐞�锛岀暥(d膩ng)鐒堕嚌灏嶉€欑ó鐤剧梾鍦ㄧ敤钘ョ墿瑾�(di脿o)鐞嗚韩楂旀檪闁撲篃瑕佹敞鎰忚鏌ユ竻妤氱梾鍥�锛岀劧鍚庡仛濂介爯(y霉)闃插伐浣�銆� 瑭虫儏
瀹夌董姹€閫欑ó钘ュ搧閬╃敤浜庤綁(zhu菐n)绉绘€х祼(ji茅)鐩磋吀鐧岋紝鎮ｈ€呮湅鍙嬪彲浠ュ湪灏堟キ(y猫)閱�(y墨)鐢熸寚灏�(d菐o)涓嬩娇鐢ㄨ┎钘ョ墿鐢ㄨ棩鐨勬檪鍊欒瑾�(r猫n)鐪熸煡鐪嬭鏄庢浉锛岃浠旂窗(x矛)浜嗚В瑾槑鏇稿収(n猫i)瀹�锛屼笉鎳傚緱鐢ㄨ棩鍟忛瑕佸強鏅傚悜?q奴)顥滻(y猫)浜哄＋鍜ㄨ锛屽垏瑷樹笉瑕佽儭浜傛搷浣�锛屽鏋滅敤娉曠敤閲忎笉姝ｇ⒑锛屽彲鑳芥渻褰遍熆钘ユ晥鐧�(f膩)鎻�銆� 瑭虫儏
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