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瀹夌珛鐢熷潶鐗囬渶鍦ㄩ啱(y墨)鐢熸寚灏�(d菐o)涓嬩娇鐢�锛屾垚浜鸿捣濮嬪姂閲忕偤绌鸿吂鎴栭€�(j矛n)椁愬悗鍙ｆ湇 5mg锛屾瘡鏃� 1 娆★紝鑻ヨ€愬彈鍙(di脿o)鏁寸偤 10mg锛屾瘡鏃� 1 娆�锛岃棩鐗囦笉鑳芥幇鍗�銆佸纰庢垨鍜€鍤�銆傚姂閲忎笉鑳介毃鎰忚(di脿o)鏁�锛屽惁鍓囧彲鑳藉姞鍔囦笉鑹弽鎳�(y墨ng)鎴�?q奴)械铏忊垙姒垈鎾囨偅?銆傝倽鑷熸悕瀹虫偅鑰呬娇鐢ㄦ檪(sh铆)闇€璎�(j菒n)鎱�锛屼腑搴︽垨閲嶅害鑲濆姛鑳芥悕瀹虫偅鑰呬笉寤鸿浣跨敤銆� 瑭虫儏
鏅瀹夛紙瀹夌珛鐢熷潶鐗囷級瀛曞│鍙婂摵涔虫湡濠﹀コ鐢ㄨ棩锛氬濞犳偅鑰咃細瀹夌珛鐢熷潶绂佺敤浜庣⒑瀵�(sh铆)鎴栧彲鑳藉凡缍�(j墨ng)鎳峰瓡鐨勫│濂炽€傚摵涔虫瘝瑕細鐩墠閭勪笉娓呮瀹夌珛鐢熷潶鏄惁鏈�(hu矛)闅ㄨ憲涔虫眮閫�(j矛n)琛屽垎娉�銆備笉鎺ㄨ枽鍦ㄦ湇鐢ㄥ畨绔嬬敓鍧︾殑鏅�(sh铆)鍊欓€�(j矛n)琛屾瘝涔冲杺椁�(y菐ng)?锛涢鍜€垛拋棣戭娊骞嶆搏h(hu谩n)澧�锛岀洝閲忎笉鍘讳綆澹撴瘮杓冮珮鐨勫北闋傛垨姘村簳銆佹捣搴曠瓑銆� 瑭虫儏
鍑＄憺鍏嬶紙瀹夌珛鐢熷潶鐗囷級閬╃敤浜庢不鐧傛湁WHOII绱�(j铆)鎴朓II绱�(j铆)鐧ョ媭鐨勮偤鍕�(d貌ng)鑴堥珮澹撴偅鑰咃紙WHO绲�1锛夛紝鐢ㄤ互鏀瑰杽閬�(y霉n)鍕�(d貌ng)鑳藉姏鍜屽欢绶╄嚚搴婃儭鍖�銆傛偅鑰呭湪鎮ｇ梾鍚庤鍔犲挤(qi谩ng)鍋氬ソ鍛煎惛璀�(h霉)鐞�锛屼繚鎸佸懠鍚搁亾閫氭殺寰堥噸瑕�锛岃鍙婃檪(sh铆)鐨勬竻鐞嗗懠鍚搁亾鐨勫垎娉岀墿锛屾纰虹殑閫�(j矛n)琛屽懠鍚搁崨鐓�锛屾瘮濡傛繁鍛煎惛绛�銆� 瑭虫儏
娉㈢敓鍧︾墖鐨勭敓鐢�(ch菐n)寤犲鏄疨atheon Inc锛岄仼鐢ㄤ簬娌荤檪WHO鍔熻兘鍒嗙礆(j铆)II绱�(j铆)-IV绱�(j铆)鐨勮偤鍕�(d貌ng)鑴堥珮澹擄紙PAH锛夛紙WHO绗�1绲勶級鐨勬偅鑰咃紝浠ユ敼鍠勬偅鑰呯殑閬�(y霉n)鍕�(d貌ng)鑳藉姏鍜屾笡灏戣嚚搴婃儭鍖�銆傜洰鍓嶏紝钘ョ墿琚磵鍏ラ啱(y墨)淇�锛屽叿楂旂殑鍍�(ji脿)鏍兼儏娉佽鍦ㄩ啱(y墨)闄㈠拰钘ユ埧鍜ㄨ銆� 瑭虫儏
瀹夌珛鐢熷潶鐗囩敤浜庢不鐧傛湁 WHOII 绱�(j铆)鎴� III 绱�(j铆)鐧ョ媭鐨勮偤鍕�(d貌ng)鑴堥珮澹撴偅鑰�锛屽湪鐗圭櫦(f膩)鎬ф垨閬哄偝鎬ц偤鍕�(d貌ng)鑴堥珮澹撲互鍙婄祼(ji茅)绶犵祫绻旂梾鐩搁棞(gu膩n)鎬ц偤鍕�(d貌ng)鑴堥珮澹撴不鐧備腑杓冪偤甯歌銆傚畠鑳芥彁鍗囨偅鑰呴亱(y霉n)鍕�(d貌ng)鑳藉姏锛屽欢绶╄嚚搴婃儭鍖栭€�(j矛n)绋嬶紝浣嗙壒鐧�(f膩)鎬ц偤绾栫董鍖栦即鎴栦笉浼寸辜鐧�(f膩)鎬ц偤鍕�(d貌ng)鑴堥珮澹撴偅鑰�銆佸皪(du矛)鍏舵垚鍒嗛亷鏁忚€呯姝娇鐢�銆� 瑭虫儏
娉㈢敓鍧︾墖鎳�(y墨ng)鍦ㄦ棭銆佹櫄閫�(j矛n)椋熷墠鎴栧悗鏈嶇敤锛屾帹钖﹀姂閲忓拰鍔戦噺瑾�(di脿o)鏁存湰鍝佺殑鍒濆鍔戦噺鐐轰竴澶�2娆�銆佹瘡娆�62.5mg锛屾寔绾�(x霉)4鍛�锛岄毃鍚庡鍔犺嚦鎺ㄨ枽鐨勭董鎸佸姂閲�125mg锛屼竴澶�2娆�锛涢珮浜庝竴澶�2娆�銆佷竴娆�125mg鐨勫姂閲忎笉鏈�(hu矛)甯朵締瓒充互鎶垫秷鑲濇瘨鎬чⅷ(f膿ng)闅�(xi菐n)澧炲姞鐨勯澶栫泭铏�銆� 瑭虫儏
鑲哄嫊(d貌ng)鑴堥珮澹撴檪(sh铆)鏈夌櫦(f膩)鐢�锛屽缓璀版偅鑰呯⿳妤电殑閭勭敤钘ョ墿渚嗚檿鐞�銆傞Μ鏄旈ò鍧︾墖鍙互鎳�(y墨ng)灏�(du矛)鐥呮儏锛岃€岃棩鐗╁彲浠ュ湪閱�(y墨)闄㈠拰钘ユ埧璩�(g貌u)璨�锛屼笉閬庡叾绂佸繉锛氬濞狅細鍦ㄥソ濞犲│濂充腑鎳�(y墨ng)鐢ㄦ湰鍝佸彲鑳芥渻(hu矛)灏�(d菐o)鑷磋儙鍏掓悕瀹筹紱棣様楱板潶鐗囩鐢ㄤ簬瀛曞│锛涘湪鍕�(d貌ng)鐗╃爺绌朵腑锛岄Μ鏄旈ò鍧﹂’绀哄嚭鑷寸暩浣滅敤锛涘鏋滃湪濡婂鏈熼枔鎳�(y墨ng)鐢ㄨ┎钘�锛屾偅鑰呮噳(y墨ng)琚憡鐭ュ彲鑳芥渻(hu矛)灏�(du矛)鑳庡厭鐢�(ch菐n)鐢熺殑鍗卞銆� 瑭虫儏
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鍑＄憺鍏嬶紙瀹夌珛鐢熷潶鐗囷級鍏掔鐢ㄨ棩锛氱洰鍓嶅皻鐒￠棞(gu膩n)浜庢湰钘ュ湪鍏掔鎮ｈ€呬腑鎳�(y墨ng)鐢ㄧ殑瀹夊叏鎬у拰鏈夋晥鎬ф暩(sh霉)鎿�(j霉)?锛涢鍜磋盁鐩熷簫^绋嬩腑閭勬噳(y墨ng)閬靛惊閱�(y墨)鍥戯紝鎸夋檪(sh铆)寰�(f霉)瑷�锛屼互渚垮京(f霉)鑳藉瑭�(p铆ng)浼版不鐧傞€�(j矛n)灞�锛屽緸鑰屾牴鎿�(j霉)瀵�(sh铆)闅涙儏娉佸皪(du矛)娌荤檪鏂规閫�(j矛n)琛屽繀瑕佺殑瑾�(di脿o)鏁淬€� 瑭虫儏
鍏ㄥ彲鍒╋紙娉㈢敓鍧︾墖锛夊湪鍏掔鎮ｈ€呬腑鎳�(y墨ng)鐢ㄧ殑瀹夊叏鎬у拰鏈夋晥鎬у皻鏈⒑绔�銆傞２椋熺鐞嗗湪鑲哄嫊(d貌ng)鑴堥珮澹撶殑璀�(h霉)鐞嗕腑涔熺櫦(f膩)鎻憲閲嶈浣滅敤?锛涢閭�?y墨ng)鐣�(d膩ng)閬靛惊浣庨菇椋查锛岄檺鍒堕垑鐨勬敐鍏�锛屼互鎺у埗琛€澹撳苟娓涜紩蹇冭嚐璨�(f霉)鎿�(d膩n)銆傚悓鏅�(sh铆)锛屼繚鎸佸潎琛￠２椋燂紝澧炲姞瀵屽惈绾栫董绱犵殑椋熷搧锛屽姘存灉銆佽敩鑿滅瓑锛屾湁鍔╀簬淇冮€�(j矛n)鑵搁亾鍋ュ悍锛岄檷浣庨珨閲嶏紝娓涜紩蹇冭偤璨�(f霉)鎿�(d膩n)銆� 瑭虫儏
鏇插墠鍒楀凹鐖炬敞灏勬恫锛屾€х媭锛氭湰钘ュ搧鐐虹劇鑹茶嚦寰粌鑹茬殑婢勬槑娑查珨銆傜敤钘ユ湡闁撻倓瑕佹敞鎰忚棩鐗╃殑淇濆瓨鏂瑰紡锛岃┎钘ュ搧閫氬父闇€鍐疯棌淇濆瓨锛屼篃瑕佺⒑淇濊棩鐗╁湪淇濊唱(zh矛)鏈熷収(n猫i)浣跨敤锛屽洜姝ゅ湪浣跨敤鍓嶈妾㈡煡钘ョ墿鏄惁璁婅唱(zh矛)鎴栭亷鏈�锛岄伩鍏嶄娇鐢ㄤ笉鍚堟牸钘ュ搧銆� 瑭虫儏
鍏ㄥ彲鍒╋紙娉㈢敓鍧︾墖锛夌敤娉曠敤閲忥細娉㈢敓鍧︾墖鎳�(y墨ng)鐢辨湁娌荤檪鑲哄嫊(d貌ng)鑴堥珮澹撹睈瀵岀稉(j墨ng)椹�(y脿n)鐨勯啱(y墨)鐢熸焙瀹氭槸鍚﹂枊濮嬫湰钘ユ不鐧傦紝骞跺皪(du矛)娌荤檪閬庣▼閫�(j矛n)琛屽毚(y谩n)鏍肩洠(ji膩n)娓�(c猫)銆傛帹钖﹀姂閲忓拰鍔戦噺瑾�(di脿o)鏁存湰鍝佺殑鍒濆鍔戦噺鐐轰竴澶�2娆�銆佹瘡娆�62.5mg锛屾寔绾�(x霉)4鍛�锛岄毃鍚庡鍔犺嚦鎺ㄨ枽鐨勭董鎸佸姂閲�125mg锛屼竴澶�2娆�銆� 瑭虫儏
鍌叉ǜ鑸掞紙棣様楱板潶鐗囷級鍏烽珨鐨勫児(ji脿)鏍奸渶瑕佹牴鎿�(j霉)钘ョ墿椤炲瀷姹哄畾锛岀敤钘ユ湡闁撴噳(y墨ng)鍤�(y谩n)鏍奸伒閱�(y墨)鍥�銆傜恫(w菐ng)涓婅卜钘ユ偅鑰呭彲浠ヤ締鐩婅棩搴峰痉妯傚ぇ钘ユ埧璩�(g貌u)璨�?锛涢鍜磋鐤俱€庣瑺顎涜▽?qi谩ng)鍋氬ソ鐩搁棞(gu膩n)鐨勮(h霉)鐞嗘帾鏂�锛屾笡杓曡嚜宸辩殑鑷ㄥ簥鐧ョ媭锛岄伩鍏嶈嚜宸辩殑鐥呮儏鎯″寲銆傝椁�(y菐ng)鎴愬ソ鐨勪綔鎭(gu墨)寰�锛屼繚璀夎嚜宸辩殑鏃ュ父鐢熸椿銆� 瑭虫儏
鍑＄憺鍏嬶紙瀹夌珛鐢熷潶鐗囷級鍏烽珨鐨勫児(ji脿)鏍奸渶瑕佹牴鎿�(j霉)钘ョ墿椤炲瀷姹哄畾锛岀敤钘ユ湡闁撴噳(y墨ng)鍤�(y谩n)鏍奸伒閱�(y墨)鍥�銆傜恫(w菐ng)涓婅卜钘ユ偅鑰呭彲浠ヤ締鐩婅棩搴峰痉妯傚ぇ钘ユ埧璩�(g貌u)璨�?锛涢鍜€磠(di脿o)鏁村ソ鑷繁鐨勬儏绶掔媭鎱�(t脿i)锛岃瀛�(xu茅)鏈�(hu矛)鎺у埗鑷繁鐨勬儏绶�锛岄伩鍏嶇穵寮�銆佺劍鎱垨鎯呯窉娉㈠嫊(d貌ng)澶х瓑鐨勫晱椤�銆� 瑭虫儏
鍌叉ǜ鑸掞紙棣様楱板潶鐗囷級绂佸繉锛氬濞狅細鍦ㄥソ濞犲│濂充腑鎳�(y墨ng)鐢ㄦ湰鍝佸彲鑳芥渻(hu矛)灏�(d菐o)鑷磋儙鍏掓悕瀹�銆傛湰鍝佺鐢ㄤ簬瀛曞│銆傚湪鍕�(d貌ng)鐗╃爺绌朵腑锛岄Μ鏄旈ò鍧﹂’绀哄嚭鑷寸暩浣滅敤?锛涢鍛栨ⅱ閰濄劅^鎴掔厵銆佹帶鍒堕珨閲嶇瓑鏂规硶渚嗚(di脿o)鐞嗚嚜宸辩殑鐥呮儏锛岃(di脿o)鏁村ソ鑷繁鐨勭敓娲绘柟寮忥紝娓涘皯灏�(du矛)鑲洪儴閫犳垚鐨勫奖闊�銆� 瑭虫儏
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鐢ㄨ棩鍏ㄧ▼鎸囧皫(d菐o)
寤犲鎺堟瑠(qu谩n) 姝ｅ搧娓犻亾
瀹夊叏鏀惧績 闅辩閰嶉€�
