璩�(g貌u)鐗╂寚鍗�
璩�(g貌u)鐗╀繚闅�
鏀粯鏂瑰紡
閰嶉€佹湇鍕�(w霉)
鍞悗鏈嶅嫏(w霉)
闂�(gu膩n)浜庢垜鍊�
钘ョ墿鐨勫悎鐞嗕娇鐢ㄥ緢閲嶈锛屾瓙鐙勬矁锛堢磵姝﹀埄灏ゅ柈鎶楁敞灏勬恫锛夋帹钖﹀姂閲忕偤3mg/kg锛岄潨鑴堟敞灏勬瘡2鍛ㄤ竴娆★紝姣忔鎸佺簩(x霉)60鍒嗛悩锛岀洿鑷冲嚭鐝�(xi脿n)鐤剧梾閫�(j矛n)灞曟垨鐢�(ch菐n)鐢熶笉鍙帴鍙楃殑姣掓€�銆傛偅鑰呭湪鐢ㄨ棩鏈熼枔鎳�(y墨ng)閬垮厤鑷瑾�(di脿o)鏁村姂閲忔垨鍋滆棩锛屼互鍏嶅奖闊挎不鐧傞€�(j矛n)绋嬨€� 瑭虫儏
钘ョ墿鐨勭蹇屾槸鎮ｈ€呴渶瑕佷簡瑙ｇ殑閲嶉粸(di菐n)锛屾敞灏勭敤鏀剧窔(xi脿n)鑿岀礌D绂佸繉鏄湁鎮ｆ按鐥樼梾鍙茶€呭繉鐢ㄣ€傜敤钘ユ湡闁�锛屾偅鑰呮噳(y墨ng)閬╃暥(d膩ng)閫�(j矛n)琛岄珨鑲查崨鐓�锛屽鏁ｆ銆佺憸浼界瓑锛屼互澧炲挤(qi谩ng)韬珨鐨勬姷鎶楀姏銆傚績鐞嗚(h霉)鐞嗗悓妯ｉ噸瑕�锛屾偅鑰呮噳(y墨ng)淇濇寔妯�(l猫)瑙€鐨勫績鎱�(t脿i)锛岄伩鍏嶉亷(gu貌)搴︾劍鎱拰绶婂嫉銆� 瑭虫儏
瀛熼鍙哥壒閳夌墖鍍�(ji脿)鏍煎彈寰堝鍥犵礌鐨勫奖闊�锛屼笉鍚岀殑鍦版柟璨�(m菐i)钘ョ墿鍞児(ji脿)涓嶄竴妯�锛岀泭钘ュ悍寰锋▊(l猫)澶ц棩鎴挎槸鏈夐姺(xi膩o)鍞棩鐗╃殑锛屾瑕�(gu墨)鍦版柟璨�(m菐i)钘ョ墿锛屽児(ji脿)鏍煎彲浠ュ緱鍒颁繚闅滅殑銆傞啱(y墨)淇濊兘鍚﹀牨(b脿o)閵�(xi膩o)閫欐钘ョ墿涔熷彲浠ュ挩瑭�(x煤n)閱�(y墨)钘ュ斧锛屼粬鍊戞渻(hu矛)鐐哄ぇ瀹跺仛瑙ｇ瓟鐨勩€� 瑭虫儏
娑堢檶骞崇墖鏄彲浠ュ湪涓€浜涙瑕�(gu墨)鐨勯啱(y墨)闄㈡垨鑰呰棩鎴胯臣(g貌u)璨�(m菐i)鐨�锛屽缓璀拌閫氶亷(gu貌)姝ｈ(gu墨)閫斿緫璨�(m菐i)钘ョ墿锛岀泭钘ュ悍寰锋▊(l猫)澶ц棩鎴挎槸鏈夐姺(xi膩o)鍞棩鐗�锛屾瑕�(gu墨)閫斿緫璨�(m菐i)钘ユ垜鏄湁淇濋殰鐨勶紝閫欐钘ョ墿寤鸿閬告搰鍦ㄥ(sh铆)楂斿簵璩�(g貌u)璨�(m菐i)锛屽洜?y脿n)妯楊彆鍒囨灠顎硜鈹ㄥ箯缍墈璀夌殑锛屽湪缍�(w菐ng)涓婅臣(g貌u)璨�(m菐i)鍙兘涓嶆槸寰堟柟渚�銆傝卜(m菐i)鍥炰締(l谩i)鐨勮棩鐗╀篃瑕佸挩瑭�(x煤n)閱�(y墨)甯�锛岀劧鍚庡皪(du矛)鐧ョ敤钘�锛岄€�(j矛n)琛岃韩楂旂殑瑾�(di脿o)鐞�銆� 瑭虫儏
闈炲皬绱�(x矛)鑳炶偤鐧岄渶瑕佺⿳妤电殑鐢ㄨ棩锛屾槗鐟炴矙鐨勬帹钖﹀姂閲忕偤250mg(1鐗�)锛屼竴鏃�1娆�锛屽彛鏈�锛岀┖鑵规垨鑸囬鐗╁悓鏈嶇洿鍒板嚭鐝�(xi脿n)鐤剧梾閫�(j矛n)灞曟垨涓嶈兘鑰愬彈鐨勬瘨鎬�锛涘鏋滄紡鏈嶆湰鍝佷竴娆★紝鎳�(y墨ng)鍦ㄦ偅鑰呰璧峰悗鐩″揩鏈嶇敤锛涘鏋滆窛闆笅娆℃湇钘ユ檪(sh铆)闁撲笉瓒�12灏忔檪(sh铆)锛屽墖鎮ｈ€呬笉鎳�(y墨ng)鍐嶆湇鐢ㄦ紡鏈嶇殑钘ョ墿銆� 瑭虫儏
瀹夋浛鍙啝鍥婁笉鑹弽鎳�(y墨ng)锛氬皯鏁�(sh霉)鎮ｈ€呬娇鐢ㄥ悗鍙嚭鐝�(xi脿n)鎯″績銆佽璞￠檷浣�锛涢亷(gu貌)閲�銆侀€ｇ簩(x霉)涔呮湇鍙嚧蹇冩厡锛涢绠＄檶鎮ｈ€呭湪浣跨敤钘ョ墿鏈熼枔鍙兘鏈�(hu矛)鎯″績鐨勬儏娉佺櫦(f膩)鐢�锛屼絾鏄笉鍚岀殑鎮ｈ€呭皪(du矛)钘ョ墿鐨勮€愬彈鎬ф槸涓嶄竴妯ｇ殑锛岄偅涔堢敤钘ュ悗鐨勫弽鎳�(y墨ng)涔熶笉鐩稿悓锛屽缓璀扮敤钘ョ殑鎮ｈ€呴兘瑕佸瑙€瀵熶娇鐢ㄨ棩鐗╀箣鍚庤韩楂旂殑琛ㄧ従(xi脿n)锛岀櫦(f膩)鐝�(xi脿n)涓嶈壇鍙嶆噳(y墨ng)鍚庡強鏅�(sh铆)鐨勮(di脿o)鏁�銆� 瑭虫儏
涔宠吅鐧屾槸鎴愬勾濂虫€х兢楂旂暥(d膩ng)涓瘮杓冨父瑕�(ji脿n)鐨勪竴绋叓鐦�锛屾湁鐨勯渶瑕佹帴鍙楁墜琛�(sh霉)娌荤檪锛岃€屾湁鐨勬偅鑰呭墖瑕佹帴鍙楄棩鐗╂不鐧�銆傚叾涓硶妯�(l猫)閫氶仼鐢ㄤ簬娌荤檪绲曠稉(j墨ng)鍚庡│濂抽泴婵€绱犲彈楂旈櫧(y谩ng)鎬�/鎴栦笉瑭�?sh霉)闇揇(zhu菐n)绉绘€т钩鑵虹檶锛岀暥(d膩ng)鍓嶉啱(y墨)闄㈠拰钘ユ埧閮芥槸鏈夐€欑ó钘ョ墿鍑哄敭鐨勶紝鍙互鍘诲挩瑭�(x煤n)浜嗚В銆� 瑭虫儏
娉ㄥ皠鐢ㄥ攽渚�(l谩i)鑶﹂吀娉ㄦ剰浜嬮爡(xi脿ng)锛� 1. 棣栨浣跨敤鑹炬湕鏅�(sh铆)鎳�(y墨ng)瀵嗗垏鐩�(ji膩n)娓�(c猫)琛€娓呬腑閳�銆佺７銆侀巶浠ュ強琛€娓呰倢閰搁厫鐨勬按骞�锛屽鍑虹従(xi脿n)琛€娓呬腑閳�銆佺７鍜岄巶鐨勫惈閲忛亷(gu貌)浣�锛屾噳(y墨ng)绲︿簣蹇呰鐨勮(b菙)鍏呮不鐧�锛� 2. 浼存湁鎯℃€ч珮閳ｈ鐧ユ偅鑰呯郸浜堣壘鏈楀墠鎳�(y墨ng)鍏呭垎瑁�(b菙)姘达紝鍒╁翱鍔戣垏鑹炬湕鍚堢敤鏅�(sh铆)鍙兘鍦ㄥ厖鍒嗚(b菙)姘村悗浣跨敤锛屾湰鍝佽垏鍏锋湁鑵庢瘨鎬х殑钘ョ墿鍚堢敤鏅�(sh铆)鎳�(y墨ng)鎱庨噸锛� 3. 鎺ュ彈鑹炬湕娌荤檪鏅�(sh铆)锛屽鍑虹従(xi脿n)鑵庡姛鑳芥儭鍖�锛屾噳(y墨ng)鍋滆棩鑷宠厧鍔熻兘鎭㈠京(f霉)鑷冲熀绶�(xi脿n)姘村钩锛� 4. 灏�(du矛)闃垮徃鍖规灄閬�(gu貌)鏁忕殑鍝枠鎮ｈ€呮噳(y墨ng)鎱庣敤鑹炬湕銆� 瑭虫儏
鐧借鐥呮槸涓€绋棦鍙互鍑虹従(xi脿n)鍦ㄥ厭绔ヨ韩涓婁篃鍙互鍑虹従(xi脿n)鍦ㄦ垚骞寸兢楂旇韩涓婄殑鐤剧梾锛岄渶瑕佸灏�(du矛)鐥呮儏閫�(j矛n)琛屼簡瑙�锛屾湁闇€瑕佺殑鏅�(sh铆)鍊欓倓闇€瑕佺敤钘ユ不鐧�銆傝€岀儚鑻編鍙哥墖鐢ㄦ硶鐢ㄩ噺锛氭垚浜�锛屼竴鏃�30mg锛�3鐗囷級锛屼竴娆★紙鏃╂櫒绌鸿吂鍙ｆ湇锛夋垨鍒�3娆″彛鏈�锛涘厭绔ラ厡娓涳紝鎴栭伒閱�(y墨)鍥�锛涘鐧ョ媭绶╄В锛屽彲姣忓懆鏈嶇敤2锝�3娆�銆� 瑭虫儏
钘ョ墿鐨勪綔鐢ㄥ拰鍔熻兘涓绘不锛岀蹇岄(l猫i)鐨勬儏娉佹槸鎮ｈ€呴渶瑕佷簡瑙ｇ殑銆傛嘲閬撶敤浜庢不鐧傛柊瑷烘柗鐨勫褰㈡€ц啝璩�(zh矛)姣嶇窗(x矛)鑳炵槫锛岄枊(k膩i)濮嬪厛鑸囨斁鐧傝伅(li谩n)鍚堟不鐧�锛岄毃鍚庝綔鐐鸿紨鍔╂不鐧�锛涘父瑕�(gu墨)娌荤檪鍚庡京(f霉)鐧�(f膩)鎴栭€�(j矛n)灞曠殑澶氬舰鎬ц啝璩�(zh矛)姣嶇窗(x矛)鑳炵槫鎴栭枔璁婃€ф槦褰㈢窗(x矛)鑳炵槫锛涘叾娆�锛岃棩鐗╃殑绂佸繉锛氬皪(du矛)鏈棩鎴栭仈(d谩)鍗″反鍡亷(gu貌)鏁�銆佸濞犳湡銆佸毚(y谩n)閲嶉楂撴姂鍒剁殑鎮ｈ€呯鐢ㄣ€� 瑭虫儏
琛€灏忔澘娓涘皯鍟�(w猫n)椤屽彲鑳借浣跨敤钘ョ墿渚�(l谩i)铏曠悊锛岃€屽悍鑹炬壎姝ｈ啝鍥婃硶鐢ㄩ噺锛氬彛鏈嶏紝涓€娆�1-2绮�锛屼竴鏃�3娆°€傛牴鎿�(j霉)瑾�(shu艒)鏄庢浉(sh奴)锛屽悍鑹炬壎姝ｈ啝鍥婄殑淇濊唱(zh矛)鏈熺偤36鍊�(g猫)鏈堢浉灏�(du矛)杓冮暦(zh菐ng)锛屼絾鏄偅鑰呴倓鏄娉ㄦ剰鍦ㄧ敤钘ヤ腑鏌ョ湅钘ョ墿淇濊唱(zh矛)鏈�锛岄伩鍏嶈鏈嶉亷(gu貌)鏈熺殑钘ョ墿銆� 瑭虫儏
娉ㄥ皠鐢ㄥ攽渚�(l谩i)鑶﹂吀涓昏鎴愪唤鐐哄攽渚�(l谩i)鑶﹂吀锛屽叾鍖栧(xu茅)鍚嶇ū(ch膿ng)鐐猴細2-锛堝挭鍞�-1-鍩猴級-1-缇ュ熀涔欑兎-1,1-浜岀７閰镐竴姘村悎鐗�锛涙湰钘ョ墿鏄睙铇囨亽鐟為啱(y墨)钘ヨ偂浠芥湁闄愬叕鍙告墍鐢熺敘(ch菐n)鐨勮檿鏂硅棩锛屽児(ji脿)鏍肩◢楂�锛屼竴鑸渶瑕佸湪绶�(xi脿n)涓嬬殑瀵�(sh铆)楂旈杸(m茅n)搴楁垨鑰呮槸閱�(y墨)闄㈡墠鑳借臣(g貌u)璨�(m菐i)鍒般€� 瑭虫儏
椋熺鐧屾槸鍙兘鏈�(hu矛)鍑虹従(xi脿n)鍦ㄤ笉鍚岀兢楂旇韩涓婄殑涓€绋檶鐧�锛屽畨鏇垮彲鑶犲泭鍙互鐢ㄤ簬椋熺鐧岀殑娌荤檪锛屼絾鏄皪(du矛)浜庡瓡濠﹁€岃█骞朵笉閬╁悎鏈嶇敤钘ョ墿锛屼笉瑕佺涓嬭嚜琛岀敤钘ャ€傚皪(du矛)浜庣鍚堜娇鐢ㄨ姹傜殑鎮ｈ€呰€岃█锛屾纰虹殑鐢ㄦ硶鐢ㄩ噺鏄彛鏈�锛屼竴娆�2绮�锛屼竴鏃�3娆★紝椋悗鏈嶇敤锛涚檪绋�6鍛�锛屾垨閬甸啱(y墨)鍥戙€� 瑭虫儏
鍦ㄦ噳(y墨ng)灏�(du矛)鐥呮儏閬�(gu貌)绋嬬暥(d膩ng)涓紝鏄惁鑳藉闀�(zh菐ng)鏅�(sh铆)闁撶殑浣跨敤钘ョ墿鏅�(sh铆)闇€瑕佸挩瑭�(x煤n)閱�(y墨)鐢熺殑銆傛嘲閬撳皪(du矛)鏂拌ê鏂风殑澶氬舰鎬ц啝璩�(zh矛)姣嶇窗(x矛)鑳炵槫鐨勬垚浜烘偅鑰咃細鍚屾鏀惧寲鐧傛湡鍙ｆ湇鏈搧锛�75mg/m2/鏃ワ紝鍏�42澶�锛屽悓鏅�(sh铆)鎺ュ彈鏀剧檪锛涢毃鍚庢帴鍙�6鍊�(g猫)鍛ㄦ湡鐨勬湰鍝佽紨鍔╂不鐧�锛涙牴鎿�(j霉)鎮ｈ€呰€愬彈绋嬪害鍙毇鍋滅敤钘ワ紝浣嗙劇(w煤)闇€闄嶄綆鍔戦噺銆� 瑭虫儏
濂ф媺甯曞埄鐗囧嚭鍞児(ji脿)鏍煎苟娌�(m茅i)鏈夊緢鏄傝泊锛屼笉閬�(gu貌)鐣�(d膩ng)鍓嶅湪甯傞潰涓婂悇澶у(sh铆)楂旇棩搴楃殑璩�(m脿i)鍍�(ji脿)涔熶笉鏄悓涓€妯�(bi膩o)婧�(zh菙n)鐨�锛屽悇浣嶅鏋滄兂瑕佷簡瑙ｅ叿楂旀儏娉侊紝鍙互鎶芥檪(sh铆)闁撳幓鐩婅棩搴峰痉妯�(l猫)澶ц棩鎴垮挩瑭�(x煤n)涓€涓嬪皥(zhu膩n)妤�(y猫)浜哄＋銆� 瑭虫儏
楣介吀鍩冨厠鏇垮凹鐗囧嚭鍞児(ji脿)鏍肩洰鍓嶅湪甯傞潰涓婂苟涓嶆槸绲�(t菕ng)涓€妯�(bi膩o)婧�(zh菙n)鐨�锛屽彲鑳芥渻(hu矛)鍥�?y脿n)姗愭亶鈹洨鍥燁墐l(f膩)鐢熻畩鍖栵紝鏈�(hu矛)鏈変笂涓嬫诞鍕�(d貌ng)鐨勬儏娉�锛屽鏋滃悇浣嶉渶瑕佷簡瑙ｈ棩鐗╄┏绱�(x矛)鍍�(ji脿)鏍硷紝鎳�(y墨ng)瑭茶嚜宸卞埌鍑哄敭鍦伴粸(di菐n)鍘诲挩瑭�(x煤n)銆� 瑭虫儏
濂ф媺甯曞埄鐗囨帹钖﹀姂閲忕偤300mg锛�2鐗�150mg鐗囧姂锛夛紝姣忔棩2娆�锛岀浉鐣�(d膩ng)浜庢瘡鏃ョ附鍔戦噺鐐�600mg锛�100mg鐗囧姂鐢ㄤ簬鍔戦噺娓涘皯鏅�(sh铆)浣跨敤锛屽灞噳(y墨ng)瑭茬洠(ji膩n)鐫ｆ偅鑰呮寜鐓ф纰虹殑鏂规硶锛屾纰虹殑鐢ㄩ噺鍘讳娇鐢ㄨ紨鍔╂不鐧傜柧鐥呯殑钘ュ搧锛岀洝閲忎笉瑕佺櫦(f膩)鐢熼亷(gu貌)閲忕敤钘ョ殑鎯呮硜锛屽苟涓旂敤钘ラ殠娈典篃鎳�(y墨ng)瑭茬潱淇冧粬鍊戣獚(r猫n)鐪熷仛濂芥敞鎰忎簨闋�(xi脿ng)銆� 瑭虫儏
宸︾敳鐙€鑵虹礌閳夌墖鎳�(y墨ng)浜庢棭椁愬墠鍗婂皬鏅�(sh铆)锛岀┖鑵瑰皣涓€鏃ュ姂閲忎竴娆℃€х敤閬╃暥(d膩ng)娑查珨(渚嬪鍗婃澂姘�)閫佹湇?锛涢閭�?y墨ng)瑭茶娉ㄦ剰鍦ㄦ瘡澶╁浐瀹氱殑鏅�(sh铆)闁撶敤钘�锛屽苟涓旇鎶婃彙娌荤檪鏈熼枔鐨勭窗(x矛)绡€(ji茅)宸ヤ綔鍜屾敞鎰忎簨闋�(xi脿ng)锛岄€欐ǎ鎵嶆湁鍙兘鍦ㄦ不鐧傞亷(gu貌)绋嬩腑寰楀埌瓒冲鐨勫公鍔┿€� 瑭虫儏
鍎�(y艒u)鐢叉▊(l猫)鍙ｆ湇绲﹁棩鍚�3锝�5澶╃櫦(f膩)鐢熶綔鐢�锛屽乏鐢茬媭鑵虹礌鑸囩壒瀹氱殑杞�(zhu菐n)閬�(y霉n)铔嬬櫧鐨勭祼(ji茅)鍚堢巼妤甸珮锛屽ぇ绱勭偤99.97锛�銆傛瘡鍊�(g猫)钘ュ搧鍦ㄤ汉楂斾腑鐨勪唬璎濇檪(sh铆)闁撲互鍙婄櫦(f膩)鎻綔鐢ㄧ殑鏅�(sh铆)闁撻兘鏄瓨鍦ㄥ€�(g猫)楂斿樊鐣版€х殑锛岄€氬父瑾�(shu艒)鏄庢浉(sh奴)鐨勫収(n猫i)瀹瑰彧鑳藉浣滅偤鍙冭€�銆� 瑭虫儏
楣介吀?锛熼濠哄礊顑皾瀚犲箼妗ｈ伒?l猫)澶ц棩鎴跨洰鍓嶆湁璩�(m脿i)鐨勶紝鍚勪綅鍦ㄨ臣(g貌u)璨�(m菐i)钘ュ搧鐨勬檪(sh铆)鍊欎竴瀹氳浠旂窗(x矛)鏌ョ湅鐢熺敘(ch菐n)鏃ユ湡锛屽苟涓旇瑾�(r猫n)婧�(zh菙n)鐢熺敘(ch菐n)寤犲瑕佸皪(du矛)鐢�(ch菐n)鍝佺殑璩�(zh矛)閲忓毚(y谩n)鏍兼妸闂�(gu膩n)锛屾敞鎰忎笉瑕佷娇鐢ㄥ亣鐨勮棩鍝佹垨閬�(gu貌)鏈熻棩鍝佸幓娌荤檪鐤剧梾銆� 瑭虫儏
姝ｅ搧淇濋殰 鏀惧績閬歌臣(g貌u)
鐢ㄨ棩鍏ㄧ▼鎸囧皫(d菐o)
寤犲鎺堟瑠(qu谩n) 姝ｅ搧娓犻亾
瀹夊叏鏀惧績 闅辩閰嶉€�
